ABSTRACT
The treatment of bone defects is a difficult problem areas currently in the field of
orthopedics,the pivot methods are bone graft, bone lengthening, tissue engineering, and
bone graft is most commonly used in clinical practice. The ideal graft material should
have good biocompatibility and bone conductivity, sufficient mechanical
properties.Bone grafting materials currently used include autologous bone, allograft
bone, xenograft bone, and artificial bone . The main topic of the bone graft materials in
this project are allograft and xenograft bone materials.Considering the biocompatibility,
bone conduction, and the impact on patients and other factors, allograft and xenograft
bone materials in bone transplantation have great advantages. Xenogeneic bone material
of animal bones in this experiment come from pigs,which in anatomy, physiology,
disease mechanism are very similar with others, and a pigs have rich source.The
experimental materials are from the Shanghai Jiaotong University College of
Agriculture ,which facilitate the production of miniature pigs nearby drawn.
The research include:
1)The mechanical properties experiments of allograft and xenograft
bone.first ,regular tension, compression, bending and torsion mechanical tests for two,
followed which we focus on compression experiment of allogeneic bone under different
Process .
2)Bone porosity and three-dimensional micro-structure of allograft and xenograft.
3)Xenograft bone finite element analysis for compression,whose result compare
with the compression test.
This topic proved that xenograft bone are greater than allogeneic in tension,
compression, bending and torsional strength by mechanical properties experiments;
bone porosity of allogeneic bone is greater than xenograft bone; Finite element analysis
of compression test for xenograft bone has comparability,which is instructive to predict
the mechanical properties of bone instructive. In view of the clinical needs for a large
number of bone graft materials, the source of allograft bone is limited, but xenogenic
bone material have currently broad prospects to develop. Therefore, this topic is
designed to provide the mechanical basis for replacing allograft bone by xenograft bone
implanted to sufferer successfully in the clinical.
Key words: animal-derived bone, allograft bone, mechanical